Probenecid as an Adjuvant in the Treatment of Gonorrhoea with Penicillin.

Treatment of gonorrhoea in Singapore using penicillin plus probenecid.

Wilcox (1970), in reviewing the problems of treating gonorrhoea in South-East Asia, noted that relatively large doses of penicillin had been used in the region for the last 10 years, but that nevertheless failure rates of 30 per cent. and higher had often been reported. When treating gonorrhoea acquired in the Philippines and Hong Kong, Holmes, Johnson, and Floyd (1967a) found that treatment wi...

Gonorrhoea treated by a combination of probenecid and sodium penicillin G.

In an area with a high incidence of gonorrhoea, where strains of Neisseria gonorrhoeae having a reduced sensitivity to penicillin in vitro are common, there is an urgent need for effective routine therapy. Furthermore, when local conditions are such that diagnosis and therapy are in the hands of personnel with a limited training, treatment must be both simple and easy to administer. When the fo...

Pivampicillin hydrochloride in uncomplicated gonorrhoea.

Because of the inconvenience of injections and the serious anaphylactic reactions sometimes seen in connection with parenteral penicillin treatment, oral ampicillin has been proposed as an alternative in the treatment of gonorrhoea. Extensive studies have shown that the efficacy of ampicillin in a single dose of 2 g. combined with probenecid, or 2 g. divided into two doses with a 5-hour interva...

Treatment of gonorrhoea with procaine penicillin plus probenecid.

Three regimens of procaine penicillin G, Augmentin, and probenecid compared for treating acute gonorrhoea in men.

The efficacy of three penicillin regimens in treating uncomplicated gonorrhoea in men was evaluated. The regimens consisted of: Augmentin 3.25 g plus probenecid 1 g orally: aqueous procaine penicillin G 4.5 MIU intramuscularly and probenecid 1 g plus one tablet of Augmentin 375 mg orally; or aqueous procaine penicillin G 4.5 MIU intramuscularly and probenecid 1 g plus two tablets of Augmentin 3...